1z1c

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[[Image:1z1c.png|left|200px]]
 
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==Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice==
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The line below this paragraph, containing "STRUCTURE_1z1c", creates the "Structure Box" on the page.
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<StructureSection load='1z1c' size='340' side='right'caption='[[1z1c]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z1c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_minute_virus_(STRAIN_MVMI) Murine minute virus (STRAIN MVMI)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z1C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D5M:2-DEOXYADENOSINE-5-MONOPHOSPHATE'>D5M</scene></td></tr>
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{{STRUCTURE_1z1c| PDB=1z1c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1c OCA], [https://pdbe.org/1z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z1c RCSB], [https://www.ebi.ac.uk/pdbsum/1z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z1c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_MUMIM CAPSD_MUMIM] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z1c ConSurf].
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<div style="clear:both"></div>
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===Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16103145}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16103145 is the PubMed ID number.
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[[Category: Agbandje-McKenna M]]
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[[Category: Almendral JM]]
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{{ABSTRACT_PUBMED_16103145}}
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[[Category: Bryant N]]
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[[Category: Foces-Foces C]]
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==About this Structure==
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[[Category: Govindasamy L]]
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[[1z1c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1C OCA].
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[[Category: Hernando E]]
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[[Category: Kontou M]]
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==Reference==
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[[Category: Llamas-Saiz AL]]
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<ref group="xtra">PMID:16103145</ref><ref group="xtra">PMID:15299974</ref><references group="xtra"/>
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[[Category: McKenna R]]
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[[Category: Viruses]]
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[[Category: Nam HJ]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Rubio MP]]
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[[Category: Almendral, J M.]]
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[[Category: Bryant, N.]]
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[[Category: Foces-Foces, C.]]
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[[Category: Govindasamy, L.]]
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[[Category: Hernando, E.]]
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[[Category: Kontou, M.]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: McKenna, R.]]
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[[Category: Nam, H J.]]
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[[Category: Rubio, M P.]]
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[[Category: Icosahedral virus]]
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[[Category: Immunosuppressive strain]]
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[[Category: Minute virus of mice]]
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[[Category: Mvmi]]
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[[Category: Virus/dna complex]]
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Current revision

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice

PDB ID 1z1c

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