3c8q

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[[Image:3c8q.png|left|200px]]
 
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==Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme==
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The line below this paragraph, containing "STRUCTURE_3c8q", creates the "Structure Box" on the page.
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<StructureSection load='3c8q' size='340' side='right'caption='[[3c8q]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2nzb 2nzb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_3c8q| PDB=3c8q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8q OCA], [https://pdbe.org/3c8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8q RCSB], [https://www.ebi.ac.uk/pdbsum/3c8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/3c8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c8q ConSurf].
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<div style="clear:both"></div>
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===Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19384988 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia virus T4]]
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{{ABSTRACT_PUBMED_19384988}}
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[[Category: Large Structures]]
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[[Category: Mooers BHM]]
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==About this Structure==
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[[3c8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8Q OCA].
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==Reference==
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<ref group="xtra">PMID:19384988</ref><ref group="xtra">PMID:19384984</ref><references group="xtra"/>
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[[Category: Enterobacteria phage t4]]
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[[Category: Lysozyme]]
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[[Category: Mooers, B H.M.]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriolytic enzyme]]
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[[Category: Charge burial]]
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[[Category: Electrostatic calculation]]
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[[Category: Electrostatic]]
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[[Category: Glycosidase]]
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[[Category: Hydrogen bonding]]
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[[Category: Hydrolase]]
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[[Category: Mutational analysis]]
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[[Category: Pka shift]]
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[[Category: Protein engineering]]
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[[Category: Steric strain]]
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[[Category: T4 lysozyme]]
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[[Category: Thermal stability]]
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Current revision

Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme

PDB ID 3c8q

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