2jes

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[[Image:2jes.png|left|200px]]
 
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==Portal protein (gp6) from bacteriophage SPP1==
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The line below this paragraph, containing "STRUCTURE_2jes", creates the "Structure Box" on the page.
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<StructureSection load='2jes' size='340' side='right'caption='[[2jes]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jes]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_SPP1 Bacillus phage SPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JES FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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{{STRUCTURE_2jes| PDB=2jes | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jes OCA], [https://pdbe.org/2jes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jes RCSB], [https://www.ebi.ac.uk/pdbsum/2jes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jes ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PORTL_BPSPP PORTL_BPSPP] Forms the portal vertex of the capsid (PubMed:17363899). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine.<ref>PMID:17363899</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jes_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jes ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tailed bacteriophages and herpesviruses load their capsids with DNA through a tunnel formed by the portal protein assembly. Here we describe the X-ray structure of the bacteriophage SPP1 portal protein in its isolated 13-subunit form and the pseudoatomic structure of a 12-subunit assembly. The first defines the DNA-interacting segments (tunnel loops) that pack tightly against each other forming the most constricted part of the tunnel; the second shows that the functional dodecameric state must induce variability in the loop positions. Structural observations together with geometrical constraints dictate that in the portal-DNA complex, the loops form an undulating belt that fits and tightly embraces the helical DNA, suggesting that DNA translocation is accompanied by a 'mexican wave' of positional and conformational changes propagating sequentially along this belt.
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===PORTAL PROTEIN FROM BACTERIOPHAGE SPP1===
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Structural framework for DNA translocation via the viral portal protein.,Lebedev AA, Krause MH, Isidro AL, Vagin AA, Orlova EV, Turner J, Dodson EJ, Tavares P, Antson AA EMBO J. 2007 Apr 4;26(7):1984-94. Epub 2007 Mar 15. PMID:17363899<ref>PMID:17363899</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2jes" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17363899}}, adds the Publication Abstract to the page
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*[[Portal protein|Portal protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17363899 is the PubMed ID number.
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*[[Portal protein 3D structures|Portal protein 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_17363899}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[2jes]] is a 26 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_spp1 Bacillus phage spp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JES OCA].
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[[Category: Bacillus phage SPP1]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Antson AA]]
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<ref group="xtra">PMID:17363899</ref><ref group="xtra">PMID:9757122</ref><ref group="xtra">PMID:1583695</ref><references group="xtra"/>
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[[Category: Dodson EJ]]
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[[Category: Bacillus phage spp1]]
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[[Category: Isidro AL]]
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[[Category: Antson, A A.]]
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[[Category: Krause MH]]
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[[Category: Dodson, E J.]]
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[[Category: Lebedev AA]]
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[[Category: Isidro, A L.]]
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[[Category: Orlova EV]]
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[[Category: Krause, M H.]]
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[[Category: Tavares P]]
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[[Category: Lebedev, A A.]]
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[[Category: Turner J]]
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[[Category: Orlova, E V.]]
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[[Category: Vagin AA]]
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[[Category: Tavares, P.]]
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[[Category: Turner, J.]]
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[[Category: Vagin, A A.]]
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[[Category: Bacteriophage spp1]]
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[[Category: Dna translocation]]
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[[Category: Molecular motor]]
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[[Category: Viral portal protein]]
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[[Category: Viral protein]]
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Current revision

Portal protein (gp6) from bacteriophage SPP1

PDB ID 2jes

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Proteopedia Page Contributors and Editors (what is this?)

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