2plb

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[[Image:2plb.png|left|200px]]
 
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==D(GTATACC) under hydrostatic pressure of 1.39 GPa==
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The line below this paragraph, containing "STRUCTURE_2plb", creates the "Structure Box" on the page.
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<StructureSection load='2plb' size='340' side='right'caption='[[2plb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2plb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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{{STRUCTURE_2plb| PDB=2plb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2plb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plb OCA], [https://pdbe.org/2plb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2plb RCSB], [https://www.ebi.ac.uk/pdbsum/2plb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2plb ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
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===D(GTATACC) under hydrostatic pressure of 1.39 GPa===
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Adaptation of the base-paired double-helix molecular architecture to extreme pressure.,Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642<ref>PMID:17617642</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17617642}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2plb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17617642 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17617642}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2plb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA].
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[[Category: Fourme R]]
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[[Category: Girard E]]
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==Reference==
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[[Category: Kahn R]]
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<ref group="xtra">PMID:17617642</ref><ref group="xtra">PMID:2911354</ref><ref group="xtra">PMID:11524565</ref><ref group="xtra">PMID:16478683</ref><references group="xtra"/>
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[[Category: Prange T]]
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[[Category: Fourme, R.]]
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[[Category: Girard, E.]]
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[[Category: Kahn, R.]]
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[[Category: Prange, T.]]
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[[Category: Crystal structure]]
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[[Category: Dna]]
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[[Category: High-pressure]]
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Current revision

D(GTATACC) under hydrostatic pressure of 1.39 GPa

PDB ID 2plb

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