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1kjr

From Proteopedia

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[[Image:1kjr.png|left|200px]]
 
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==Crystal Structure of the human galectin-3 CRD in complex with a 3'-derivative of N-Acetyllactosamine==
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The line below this paragraph, containing "STRUCTURE_1kjr", creates the "Structure Box" on the page.
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<StructureSection load='1kjr' size='340' side='right'caption='[[1kjr]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kjr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEK:2,3,5,6-TETRAFLUORO-4-METHOXY-BENZAMIDE'>BEK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1kjr| PDB=1kjr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kjr OCA], [https://pdbe.org/1kjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kjr RCSB], [https://www.ebi.ac.uk/pdbsum/1kjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kjr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kjr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kjr ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the human galectin-3 CRD in complex with a 3'-derivative of N-Acetyllactosamine===
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15701008}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15701008 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_15701008}}
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==About this Structure==
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[[1kjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJR OCA].
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==Reference==
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<ref group="xtra">PMID:15701008</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arnoux, P.]]
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[[Category: Large Structures]]
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[[Category: Kahl-Knutsson, B.]]
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[[Category: Arnoux P]]
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[[Category: Leffler, H.]]
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[[Category: Kahl-Knutsson B]]
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[[Category: Nilsson, U J.]]
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[[Category: Leffler H]]
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[[Category: Rini, J M.]]
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[[Category: Nilsson UJ]]
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[[Category: Sorme, P.]]
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[[Category: Rini JM]]
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[[Category: Sorme P]]

Current revision

Crystal Structure of the human galectin-3 CRD in complex with a 3'-derivative of N-Acetyllactosamine

PDB ID 1kjr

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