2y3w

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[[Image:2y3w.png|left|200px]]
 
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==N-terminal head domain and beginning of coiled coil domain of Danio rerio SAS-6==
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The line below this paragraph, containing "STRUCTURE_2y3w", creates the "Structure Box" on the page.
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<StructureSection load='2y3w' size='340' side='right'caption='[[2y3w]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2y3w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3w OCA], [https://pdbe.org/2y3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3w RCSB], [https://www.ebi.ac.uk/pdbsum/2y3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3w ProSAT]</span></td></tr>
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{{STRUCTURE_2y3w| PDB=2y3w | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAS6_DANRE SAS6_DANRE] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.<ref>PMID:21273447</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Centrioles are cylindrical, nine-fold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the N-terminal domain of SAS-6 from zebrafish and show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are likely essential to the structural organization of cartwheel centers.
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===N-TERMINAL HEAD DOMAIN AND BEGINNING OF COILED COIL DOMAIN OF DANIO RERIO SAS-6===
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Structures of SAS-6 Suggest Its Organization in Centrioles.,van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B Science. 2011 Jan 27. PMID:21273447<ref>PMID:21273447</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2y3w" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21273447 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21273447}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2y3w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3W OCA].
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==Reference==
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<ref group="xtra">PMID:21273447</ref><references group="xtra"/>
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[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Breugel, M Van.]]
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[[Category: Large Structures]]
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[[Category: Van Breugel M]]

Current revision

N-terminal head domain and beginning of coiled coil domain of Danio rerio SAS-6

PDB ID 2y3w

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