2jj9

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[[Image:2jj9.png|left|200px]]
 
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==Crystal structure of myosin-2 in complex with ADP-metavanadate==
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The line below this paragraph, containing "STRUCTURE_2jj9", creates the "Structure Box" on the page.
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<StructureSection load='2jj9' size='340' side='right'caption='[[2jj9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2jj9| PDB=2jj9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jj9 OCA], [https://pdbe.org/2jj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2jj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jj9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jj9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jj9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have identified pentabromopseudilin (PBP) as a potent inhibitor of myosin-dependent processes such as isometric tension development and unloaded shortening velocity. PBP-induced reductions in the rate constants for ATP binding, ATP hydrolysis and ADP dissociation extend the time required per myosin ATPase cycle in the absence and presence of actin. Additionally, coupling between the actin and nucleotide binding sites is reduced in the presence of the inhibitor. The selectivity of PBP differs from that observed with other myosin inhibitors. To elucidate the binding mode of PBP, we crystallized the Dictyostelium myosin-2 motor domain in the presence of Mg(2+)-ADP-meta-vanadate and PBP. The electron density for PBP is unambiguous and shows PBP to bind at a previously unknown allosteric site near the tip of the 50-kDa domain, at a distance of 16 A from the nucleotide binding site and 7.5 A away from the blebbistatin binding pocket.
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===CRYSTAL STRUCTURE OF MYOSIN-2 IN COMPLEX WITH ADP-METAVANADATE===
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The mechanism of pentabromopseudilin inhibition of myosin motor activity.,Fedorov R, Bohl M, Tsiavaliaris G, Hartmann FK, Taft MH, Baruch P, Brenner B, Martin R, Knolker HJ, Gutzeit HO, Manstein DJ Nat Struct Mol Biol. 2009 Jan;16(1):80-8. Epub 2009 Jan 4. PMID:19122661<ref>PMID:19122661</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19122661}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jj9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19122661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19122661}}
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==About this Structure==
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[[2jj9]] is a 1 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJ9 OCA].
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==See Also==
==See Also==
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*[[Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19122661</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Baruch, P.]]
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[[Category: Large Structures]]
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[[Category: Boehl, M.]]
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[[Category: Baruch P]]
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[[Category: Brenner, B.]]
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[[Category: Boehl M]]
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[[Category: Fedorov, R.]]
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[[Category: Brenner B]]
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[[Category: Gutzeit, H O.]]
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[[Category: Fedorov R]]
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[[Category: Hartmann, F K.]]
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[[Category: Gutzeit HO]]
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[[Category: Knoelker, H J.]]
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[[Category: Hartmann FK]]
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[[Category: Manstein, D J.]]
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[[Category: Knoelker HJ]]
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[[Category: Martin, R.]]
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[[Category: Manstein DJ]]
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[[Category: Tsiavaliaris, G.]]
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[[Category: Martin R]]
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[[Category: Tsiavaliaris G]]

Current revision

Crystal structure of myosin-2 in complex with ADP-metavanadate

PDB ID 2jj9

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