3h87
From Proteopedia
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| - | [[Image:3h87.png|left|200px]] | ||
| - | + | ==Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis== | |
| - | + | <StructureSection load='3h87' size='340' side='right'caption='[[3h87]], [[Resolution|resolution]] 1.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3h87]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H87 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h87 OCA], [https://pdbe.org/3h87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h87 RCSB], [https://www.ebi.ac.uk/pdbsum/3h87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h87 ProSAT], [https://www.topsan.org/Proteins/ISFI/3h87 TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/VAPC2_MYCTU VAPC2_MYCTU] Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2.<ref>PMID:20011113</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[3h87]] is a 4 chain structure with sequence from [ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h87_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: Min | + | </jmolCheckbox> |
| - | [[Category: Sawaya | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h87 ConSurf]. |
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Cascio D]] | ||
| + | [[Category: Eisenberg D]] | ||
| + | [[Category: Min A]] | ||
| + | [[Category: Sawaya MR]] | ||
Current revision
Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis
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