2l9r

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'''Unreleased structure'''
 
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The entry 2l9r is ON HOLD until Apr 19 2012
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==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A==
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<StructureSection load='2l9r' size='340' side='right'caption='[[2l9r]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9r OCA], [https://pdbe.org/2l9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9r RCSB], [https://www.ebi.ac.uk/pdbsum/2l9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKX31_HUMAN NKX31_HUMAN] Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.<ref>PMID:19462257</ref>
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Authors: Liu, G., Xiao, R., Lee, H.-W., Hamilton, K., Ciccosanti, C., Wang, H.B., Acton, T.B., Everett, J.K., Huang, Y.J., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
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==See Also==
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*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
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Description: Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti C]]
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[[Category: Everett JK]]
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[[Category: Hamilton K]]
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[[Category: Huang YJ]]
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[[Category: Lee H-W]]
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[[Category: Liu G]]
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[[Category: Montelione GT]]
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[[Category: Wang HB]]
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[[Category: Xiao R]]

Current revision

Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A

PDB ID 2l9r

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