This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3r0n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3r0n is ON HOLD Authors: Ramagopal, U.A., Samanta, D., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC) Descr...) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Immunoglobulin variable domain of Nectin-2== | |
| + | <StructureSection load='3r0n' size='340' side='right'caption='[[3r0n]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3r0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R0N FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HVEB, PRR2, PVRL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0n OCA], [https://pdbe.org/3r0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r0n RCSB], [https://www.ebi.ac.uk/pdbsum/3r0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r0n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PVRL2_HUMAN PVRL2_HUMAN]] Probable cell adhesion protein.<ref>PMID:9657005</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Nectins are members of the Ig superfamily that mediate cell-cell adhesion through homophilic and heterophilic interactions. We have determined the crystal structure of the nectin-2 homodimer at 1.3 A resolution. Structural analysis and complementary mutagenesis studies reveal the basis for recognition and selectivity among the nectin family members. Notably, the close proximity of charged residues at the dimer interface is a major determinant of the binding affinities associated with homophilic and heterophilic interactions within the nectin family. Our structural and biochemical data provide a mechanistic basis to explain stronger heterophilic versus weaker homophilic interactions among these family members and also offer insights into nectin-mediated transinteractions between engaging cells. | ||
| - | + | Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.,Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14836-40. Epub 2012 Aug 27. PMID:22927415<ref>PMID:22927415</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3r0n" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Almo, S C]] | ||
| + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Nathenson, S G]] | ||
| + | [[Category: Ramagopal, U A]] | ||
| + | [[Category: Samanta, D]] | ||
| + | [[Category: Atoms-to-animals: the immune function network]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Cell-adhesion molecule]] | ||
| + | [[Category: Ifn]] | ||
| + | [[Category: Ig-domain]] | ||
| + | [[Category: Nysgrc]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Virus entry receptor]] | ||
Current revision
Crystal Structure of the Immunoglobulin variable domain of Nectin-2
| |||||||||||
Categories: Human | Large Structures | Almo, S C | IFN, Atoms-to-Animals:.The Immune Function Network | Structural genomic | Nathenson, S G | Ramagopal, U A | Samanta, D | Atoms-to-animals: the immune function network | Cell adhesion | Cell-adhesion molecule | Ifn | Ig-domain | Nysgrc | Psi-biology | Virus entry receptor
