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2xpk

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[[Image:2xpk.jpg|left|200px]]
 
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==Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases==
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The line below this paragraph, containing "STRUCTURE_2xpk", creates the "Structure Box" on the page.
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<StructureSection load='2xpk' size='340' side='right'caption='[[2xpk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z0M:N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE'>Z0M</scene></td></tr>
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{{STRUCTURE_2xpk| PDB=2xpk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpk OCA], [https://pdbe.org/2xpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpk RCSB], [https://www.ebi.ac.uk/pdbsum/2xpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OGA_CLOP1 OGA_CLOP1] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Posttranslational modification of metazoan nucleocytoplasmic proteins with N-acetylglucosamine (O-GlcNAc) is essential, dynamic, and inducible and can compete with protein phosphorylation in signal transduction. Inhibitors of O-GlcNAcase, the enzyme removing O-GlcNAc, are useful tools for studying the role of O-GlcNAc in a range of cellular processes. We report the discovery of nanomolar OGA inhibitors that are up to 900,000-fold selective over the related lysosomal hexosaminidases. When applied at nanomolar concentrations on live cells, these cell-penetrant molecules shift the O-GlcNAc equilibrium toward hyper-O-GlcNAcylation with EC values down to 3 nM and are thus invaluable tools for the study of O-GlcNAc cell biology.
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===CELL-PENETRANT, NANOMOLAR O-GLCNACASE INHIBITORS SELECTIVE AGAINST LYSOSOMAL HEXOSAMINIDASES===
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Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases.,Dorfmueller HC, Borodkin VS, Schimpl M, Zheng X, Kime R, Read KD, van Aalten DM Chem Biol. 2010 Nov 24;17(11):1250-5. PMID:21095575<ref>PMID:21095575</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xpk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21095575}}, adds the Publication Abstract to the page
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*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21095575 is the PubMed ID number.
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[O-GlcNAcase|O-GlcNAcase]]
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{{ABSTRACT_PUBMED_21095575}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2xpk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:21095575</ref><references group="xtra"/>
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[[Category: Beta-N-acetylhexosaminidase]]
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[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
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[[Category: Aalten, D M.F Van.]]
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[[Category: Large Structures]]
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[[Category: Borodkin, V S.]]
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[[Category: Borodkin VS]]
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[[Category: Dorfmueller, H C.]]
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[[Category: Dorfmueller HC]]
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[[Category: Kime, R.]]
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[[Category: Kime R]]
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[[Category: Read, K D.]]
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[[Category: Read KD]]
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[[Category: Schimpl, M.]]
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[[Category: Schimpl M]]
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[[Category: Zheng, X.]]
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[[Category: Zheng X]]
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[[Category: Van Aalten DMF]]

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Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

PDB ID 2xpk

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