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3qve
From Proteopedia
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| - | [[Image:3qve.jpg|left|200px]] | ||
| - | + | ==Crystal structure of human HMG box-containing protein 1, HBP1== | |
| - | + | <StructureSection load='3qve' size='340' side='right'caption='[[3qve]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qve]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qve OCA], [https://pdbe.org/3qve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qve RCSB], [https://www.ebi.ac.uk/pdbsum/3qve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qve ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/HBP1_HUMAN HBP1_HUMAN] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<ref>PMID:10958660</ref> <ref>PMID:10562551</ref> <ref>PMID:11500377</ref> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[3qve]] is a 3 chain structure with sequence from [ | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Chaikuad | + | [[Category: Bountra C]] |
| - | [[Category: Cocking | + | [[Category: Chaikuad A]] |
| - | + | [[Category: Cocking R]] | |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Edwards | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Filippakopoulos | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Krysztofinska E]] |
| - | [[Category: Krysztofinska | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Structural genomic]] |
| - | [[Category: Ugochukwu | + | [[Category: Ugochukwu E]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Yue | + | [[Category: Yue WW]] |
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human HMG box-containing protein 1, HBP1
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