2wgh

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[[Image:2wgh.png|left|200px]]
 
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==Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.==
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The line below this paragraph, containing "STRUCTURE_2wgh", creates the "Structure Box" on the page.
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<StructureSection load='2wgh' size='340' side='right'caption='[[2wgh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2wgh| PDB=2wgh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgh OCA], [https://pdbe.org/2wgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgh RCSB], [https://www.ebi.ac.uk/pdbsum/2wgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wgh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribonucleotide reductase (RR) is an alpha(n)beta(n) (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs. RR1 is the catalytic subunit, and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1. Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP. These structures provide insights into regulation of RR by ATP or dATP. At physiological dATP concentrations, RR1 forms inactive hexamers. We determined the first X-ray structure of the RR1-dATP hexamer and used single-particle electron microscopy to visualize the alpha(6)-betabeta'-dATP holocomplex. Site-directed mutagenesis and functional assays confirm that hexamerization is a prerequisite for inhibition by dATP. Our data indicate a mechanism for regulating RR activity by dATP-induced oligomerization.
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===HUMAN RIBONUCLEOTIDE REDUCTASE R1 SUBUNIT (RRM1) IN COMPLEX WITH DATP AND MG.===
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Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.,Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG Nat Struct Mol Biol. 2011 Mar;18(3):316-22. Epub 2011 Feb 20. PMID:21336276<ref>PMID:21336276</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wgh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21336276}}, adds the Publication Abstract to the page
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21336276 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21336276}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2wgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA].
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==Reference==
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<ref group="xtra">PMID:21336276</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van Den.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Bountra C]]
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[[Category: Bountra, C.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson A]]
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[[Category: Johansson, A.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotzsch A]]
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[[Category: Kotzsch, A.]]
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[[Category: Kragh-Nielsen T]]
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[[Category: Kragh-Nielsen, T.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J.]]
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[[Category: Schueler H]]
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[[Category: Schueler, H.]]
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[[Category: Schutz P]]
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[[Category: Schutz, P.]]
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[[Category: Siponen MI]]
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[[Category: Siponen, M I.]]
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[[Category: Svensson L]]
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[[Category: Svensson, L.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Welin, R M.]]
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[[Category: Welin RM]]
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[[Category: Wisniewska, M.]]
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[[Category: Wisniewska M]]

Current revision

Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.

PDB ID 2wgh

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