2odm

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(New page: 200px<br /><applet load="2odm" size="350" color="white" frame="true" align="right" spinBox="true" caption="2odm, resolution 2.24&Aring;" /> '''Crystal structure of...)
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[[Image:2odm.jpg|left|200px]]<br /><applet load="2odm" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2odm, resolution 2.24&Aring;" />
 
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'''Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape'''<br />
 
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==Overview==
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==Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape==
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The crystal structure of a conserved leucine rich protein, YlaN, from, Staphylococcus aureus has been determined by X-ray crystallography to 2.3, A resolution. Whilst the precise function of S. aureus YlaN is unknown its, homologue in B. subtilis has been shown to be essential for cell survival, and is thought to be involved in controlling cell shape. The structure of, S. aureus YlaN provides the first view of its protein family, which, reveals that it is a novel homodimer whose subunit architecture is, comprised of an antiparallel 3 helix bundle reminiscent of the helical, arrangements seen in leucine zipper proteins. Analysis of the pattern of, sequence conservation on the structure has led to the identification of, two connected solvent exposed patches of conserved residues in each, subunit located at one end of but on opposite faces of the molecule. We, suggest that YlaN has a binding role in the cell rather than a catalytic, function and a search for its ligand is underway to accelerate its, exploitation as a target for antibiotic discovery. Proteins 2007. (c) 2007, Wiley-Liss, Inc.
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<StructureSection load='2odm' size='340' side='right'caption='[[2odm]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2odm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odm OCA], [https://pdbe.org/2odm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odm RCSB], [https://www.ebi.ac.uk/pdbsum/2odm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y995_STAAW Y995_STAAW]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2odm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a conserved leucine rich protein, YlaN, from Staphylococcus aureus has been determined by X-ray crystallography to 2.3 A resolution. Whilst the precise function of S. aureus YlaN is unknown its homologue in B. subtilis has been shown to be essential for cell survival and is thought to be involved in controlling cell shape. The structure of S. aureus YlaN provides the first view of its protein family, which reveals that it is a novel homodimer whose subunit architecture is comprised of an antiparallel 3 helix bundle reminiscent of the helical arrangements seen in leucine zipper proteins. Analysis of the pattern of sequence conservation on the structure has led to the identification of two connected solvent exposed patches of conserved residues in each subunit located at one end of but on opposite faces of the molecule. We suggest that YlaN has a binding role in the cell rather than a catalytic function and a search for its ligand is underway to accelerate its exploitation as a target for antibiotic discovery.
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==About this Structure==
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Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape.,Xu L, Sedelnikova SE, Baker PJ, Hunt A, Errington J, Rice DW Proteins. 2007 Aug 1;68(2):438-45. PMID:17469204<ref>PMID:17469204</ref>
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2ODM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODM OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape., Xu L, Sedelnikova SE, Baker PJ, Hunt A, Errington J, Rice DW, Proteins. 2007 Apr 27;68(2):438-445. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17469204 17469204]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 2odm" style="background-color:#fffaf0;"></div>
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[[Category: Staphylococcus aureus]]
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== References ==
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[[Category: Baker, P.J.]]
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<references/>
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[[Category: Errington, J.]]
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__TOC__
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[[Category: Hunt, A.]]
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</StructureSection>
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[[Category: Rice, D.W.]]
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[[Category: Large Structures]]
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[[Category: Sedelnikova, S.E.]]
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[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Xu, L.]]
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[[Category: Baker PJ]]
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[[Category: triple helix]]
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[[Category: Errington J]]
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[[Category: Hunt A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:53:27 2008''
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[[Category: Rice DW]]
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[[Category: Sedelnikova SE]]
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[[Category: Xu L]]

Current revision

Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape

PDB ID 2odm

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