2x9d

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[[Image:2x9d.jpg|left|200px]]
 
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==Tet repressor (class D) in complex with iso-7-chlortetracycline==
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The line below this paragraph, containing "STRUCTURE_2x9d", creates the "Structure Box" on the page.
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<StructureSection load='2x9d' size='340' side='right'caption='[[2x9d]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2x9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1du7 1du7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X9D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene></td></tr>
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{{STRUCTURE_2x9d| PDB=2x9d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9d OCA], [https://pdbe.org/2x9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x9d RCSB], [https://www.ebi.ac.uk/pdbsum/2x9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tetracycline antibiotics and their degradation products appear in medically treated tissues, food, soil, and manure sludge in the environment. In the context of protein interactions with various tetracyclines we performed crystal structure analyses of the tetracycline repressor in complex with weak or noninducing tetracycline derivatives. Isotetracyclines are degradation products of tetracyclines, which occur under physiological conditions. The typical framework of the antibiotic is irreversibly broken at the BC-ring connection, leading to a modified orientation of the AB to the new C*D ring fragments. The shape of the zwitterionic AB-ring fragment is unchanged and still binds to the TetR recognition site in a manner comparable to the intact antibiotic but without typical Mg(2+) chelation. This work is an example that drug degradation products can still bind to specific targets and should be discussed in light of potential and critical side effects.
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===TET REPRESSOR (CLASS D) IN COMPLEX WITH ISO-7 CHLORTETRACYCLINE===
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Recognition of drug degradation products by target proteins: isotetracycline binding to Tet repressor.,Volkers G, Petruschka L, Hinrichs W J Med Chem. 2011 Jul 28;54(14):5108-15. Epub 2011 Jul 1. PMID:21699184<ref>PMID:21699184</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2x9d" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8153629}}, adds the Publication Abstract to the page
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8153629 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8153629}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2x9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1du7 1du7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9D OCA].
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==Reference==
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<ref group="xtra">PMID:8153629</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hinrichs, W.]]
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[[Category: Large Structures]]
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[[Category: Volkers, G.]]
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[[Category: Hinrichs W]]
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[[Category: Volkers G]]

Current revision

Tet repressor (class D) in complex with iso-7-chlortetracycline

PDB ID 2x9d

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