Ribosomal protein S12

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[[Image:RPS12.png|left|200px|thumb|Crystal Structure of Ribosomal protein S12 from [[2zm6]], chain L]]
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<StructureSection load='1qzc' size='350' side='right' caption='Ribosomal protein S12 (aqua) complex with 16S RRNA helix 44 (grey), 23S RRNA helix 69 (green) and 23S RRNA SRL (pink) (PDB entry [[1qzc]])' scene=''>
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{{STRUCTURE_2zm6| PDB=2zm6 | SIZE=300| SCENE=Ribosomal_protein_S12/Cv/1 |right|CAPTION=Ribosomal protein S12 from [[2zm6]], chain L }}
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[[Ribosomal protein S12]] (RPS12) is one of the 22 proteins which belong to the small subunit of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It is involved in the translation initiation step. The images at the left and at the right correspond to one representative RPS12, ''i.e.'' the crystal structure of Ribosomal protein S12 from ''Thermus thermophilus'' ([[2zm6]], chain L).
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[[Ribosomal protein S12]] (RPS12) is one of the 21 proteins which belong to the 30S small subunit of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It is involved in the translation initiation step<ref>PMID:1725261</ref>.
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{{TOC limit|limit=2}}
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</StructureSection>
== 3D Structures of Ribosomal protein S12 ==
== 3D Structures of Ribosomal protein S12 ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Ribosomal protein S12
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=== RPS12 ===
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**[[1qzc]] - TtRPS12+16S RRNA helix+23S RRNA helix - ''Thermus thermophilus'' <br />
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**[[1pn7]] – TtRPS12+TtRPL11+P-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
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**[[1pn8]] - TtRPS12+TtRPL11+E-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
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[[1qzc]] - TtRPS12+16S RRNA helix+23S RRNA helix - ''Thermus thermophilus'' <br />
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**[[1mvr]] – EcRPS12+EcRPL11+mRNA codon+16S RRNA fragment+23S RRNA fragment – Cryo-EM - ''Escherichia coli''<br />
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[[1pn7]] – TtRPS12+TtRPL11+P-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
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[[1pn8]] - TtRPS12+TtRPL11+E-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
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[[1mvr]] – EcRPS12+EcRPL11+mRNA codon+16S RRNA fragment+23S RRNA fragment – Cryo-EM - ''Escherichia coli''<br />
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=== S12 in small ribosomal subunit ===
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[[2zm6]], [[1n36]], [[1j5e]], [[3oto]] - TtRPS12 in 30S ribosomal subunit+THX+16S RRNA <br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3kc4]] – EcRPS12 in 30S ribosomal subunit<br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]], [[3or9]], [[3ora]] - EcRPS12 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]] - TtRPS12 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]], [[1p6g]] - EcRPS12 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS12 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach<br />
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=== S12 in small + large ribosomal subunit ===
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[[1ml5]] - EcRPS12 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM<br />
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=== S12 in small ribosomal subunit+ chain release factor ===
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[[3mr8]], [[3ms0]] – TtRPS12 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA<br />
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[[3d5a]], [[3d5c]] - TtRPS12 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[2b64]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS12 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS12 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
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=== S12 in small ribosomal subunit+tRNA+mRNA ===
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[[2hgi]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2i2p]], [[2i2u]] - EcRPS12 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS12 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] - EcRPS12 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[1xnq]], [[1xnr]] - TtRPS12 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA<br />
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=== S12 in small ribosomal subunit+A-site tRNA ===
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[[2uxd]], [[2uxc]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA<br />
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=== S12 in small ribosomal subunit+P-site tRNA ===
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[[3i8g]] - TtRPS12 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS12 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS12 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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[[3i1q]] - EcRPS12 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA <br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS12 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA<br />
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=== S12 in small ribosomal subunit+A-site tRNA+P-site tRNA ===
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*Ribosomal protein S12 in part of small ribosomal subunit
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[[1ibl]], [[1ibm]] - TtRPS12 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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**[[3iy8]] - EcRPS12+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS15+EcRPS16+EcRPS17+EcRPS18+''Leishmania taretolae'' mRNA<br />
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**[[1mj1]] - EcRPS12 +EcRPS13 +EcRPL11 + Phe-tRNA + elongation factor Tu + 23S RRNA fragments – Cryo EM<br />
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**[[3ep2]], [[3eq4]] - EcRPS12 +EcRPL11 + tRNA + elongation factor Tu + 16S RRNA fragments + 23S RRNA fragments – Cryo EM<br />
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=== S12 in small ribosomal subunit+P-site tRNA+E-site tRNA ===
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**[[1zn1]] - EcRPS12 + ribosome recycling factor + 16S RRNA fragment + 23S RRNA fragments – Cryo EM<br />
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**[[3j0d]] - EcRPS12 + RPL11 + ribosome recycling factor + 16S RRNA fragment + 23S RRNA fragments – Cryo EM<br />
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[[2ow8]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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**[[3j0e]] - EcRPS12 + elongation factor G + ribosome recycling factor + 16S RRNA fragment + 23S RRNA fragments – Cryo EM<br />
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[[2b9o]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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**[[2r1g]] – TtRPS12+ TtRPS9+ TtRPS13+ 16S RRNA fragment<br />
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[[2qnh]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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}}
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==Related Structures and Topics==
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*[[LepA]]
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=== S12 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA ===
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*[[Ribosome|The Ribosome]]
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*For additional information, see: [[Translation]]
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<br />
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[[2gy9]], [[2gyb]] - EcRPS12 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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== References ==
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS12 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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<references/>
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[[3e1a]], [[3e1c]] - EcRPS12 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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=== S12 in small ribosomal subunit + antibiotics ===
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[[1i95]], [[1i97]], [[2hhh]], [[2f4v]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[1hnw]], [[1hnx]], [[1hnz]], [[1fgj]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]], [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]] - EcRPS12 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[2j00]], [[2j02]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin<br />
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[[3knj]], [[3knh]] - TtRPS12 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knn]] - TtRPS12 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin<br />
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=== S12 in small ribosomal subunit + ribosome recycling factor ===
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[[2qbd]], [[2qbf]] – EcRPS12 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[2qbh]], [[2qbj]] - EcRPS12 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS12 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet<br />
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[[1zn1]] - TtRPS12+16S RRNA fragment+23S RRNA fragment+ribosome recycling factor+ chain release factor<br />
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=== S12 in small ribosomal subunit + elongation factor ===
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[[2wri]], [[2wrk]] - TtRPS12 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS12 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS12 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[2y0u]], [[2y0w]], [[2y0y]], [[2y10]], [[2y12]], [[2y14]], [[2y16]], [[2y18]] - TtRPS12 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+ 16S RRNA+elongation factor TU<br />
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[[3fih]] - EcRPS12 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - TtRPS12 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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[[3ep2]], [[3eq3]], [[3eq4]] – EcRPS12+EcRPL11+16S RRNA fragment+23S RRNA fragment+tRNA+elongation factor TU<br />
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[[2om7]] - TtRPS12+TtRPL1+16S RRNA fragment+23S RRNA fragment+tRNA+elongation factor G<br />
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[[1mj1]] – EcRPS12+EcRPS13+EcRPL11+16S RRNA fragment+23S RRNA fragment+tRNA Phe+elongation factor TU – Cryo-EM<br />
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=== S12 in small ribosomal subunit + translation initiation factor ===
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[[1i96]] - TtRPS12 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS12 in 30S ribosomal subunit+THX+IF+16S RRNA<br />
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=== S12 in small ribosomal subunit + various proteins ===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS12 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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[[1voq]], [[1vos]], [[1vov]], [[1vox]], [[1voz]] - EcRPS12 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[2xfz]], [[2xg1]] - TtRPS12 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA<br />
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[[3deg]] - EcRPS12+EcRPL11+16S RRNA fragment+23S RRNA fragment+A-site tRNA+P-site tRNA+LEPA EF4 fragment<br />
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[[2xzm]], [[2xzn]] - RPS12 in 40S subunit+18S RRNA+RACK1 ''Tetrahymena thermophila''
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=== S12 in part of small ribosomal subunit ===
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[[3iy8]] - EcRPS12+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS15+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA<br />
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[[2r1g]] – TtRPS12+ TtRPS9+ TtRPS13+ 16S RRNA fragment<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S12 (aqua) complex with 16S RRNA helix 44 (grey), 23S RRNA helix 69 (green) and 23S RRNA SRL (pink) (PDB entry 1qzc)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S12

Updated on 16-August-2016

Related Structures and Topics


References

  1. ↑ O'Connor M, De Stasio EA, Dahlberg AE. Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin. Biochimie. 1991 Dec;73(12):1493-500. PMID:1725261

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Wayne Decatur, Jaime Prilusky

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