2okz

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(New page: 200px<br /><applet load="2okz" size="350" color="white" frame="true" align="right" spinBox="true" caption="2okz, resolution 1.800&Aring;" /> '''MVGGVV peptide deri...)
Current revision (06:29, 3 April 2024) (edit) (undo)
 
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[[Image:2okz.gif|left|200px]]<br /><applet load="2okz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2okz, resolution 1.800&Aring;" />
 
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'''MVGGVV peptide derived from Alzheimer's A-beta'''<br />
 
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==Overview==
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==MVGGVV peptide derived from Alzheimer's A-beta==
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Amyloid fibrils formed from different proteins, each associated with a, particular disease, contain a common cross-beta spine. The atomic, architecture of a spine, from the fibril-forming segment GNNQQNY of the, yeast prion protein Sup35, was recently revealed by X-ray, microcrystallography. It is a pair of beta-sheets, with the facing side, chains of the two sheets interdigitated in a dry 'steric zipper'. Here we, report some 30 other segments from fibril-forming proteins that form, amyloid-like fibrils, microcrystals, or usually both. These include, segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion, protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common, structural features are shared by amyloid diseases at the molecular level., Structures of 13 of these microcrystals all reveal steric zippers, but, with variations that expand the range of atomic architectures for, amyloid-like fibrils and offer an atomic-level hypothesis for the basis of, prion strains.
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<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
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2OKZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
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==Reference==
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</table>
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Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Eisenberg, D.]]
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[[Category: Homo sapiens]]
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[[Category: Sambashivan, S.]]
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[[Category: Large Structures]]
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[[Category: Sawaya, M.R.]]
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[[Category: Eisenberg D]]
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[[Category: steric zipper]]
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[[Category: Sambashivan S]]
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[[Category: Sawaya MR]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:58:40 2008''
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Current revision

MVGGVV peptide derived from Alzheimer's A-beta

PDB ID 2okz

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