2ol9

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(New page: 200px<br /><applet load="2ol9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ol9, resolution 0.850&Aring;" /> '''Peptide correspondi...)
Current revision (06:29, 3 April 2024) (edit) (undo)
 
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[[Image:2ol9.gif|left|200px]]<br /><applet load="2ol9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ol9, resolution 0.850&Aring;" />
 
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'''Peptide corresponding to residues 170-175 of human prion'''<br />
 
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==Overview==
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==Peptide corresponding to residues 170-175 of human prion==
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Amyloid fibrils formed from different proteins, each associated with a, particular disease, contain a common cross-beta spine. The atomic, architecture of a spine, from the fibril-forming segment GNNQQNY of the, yeast prion protein Sup35, was recently revealed by X-ray, microcrystallography. It is a pair of beta-sheets, with the facing side, chains of the two sheets interdigitated in a dry 'steric zipper'. Here we, report some 30 other segments from fibril-forming proteins that form, amyloid-like fibrils, microcrystals, or usually both. These include, segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion, protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common, structural features are shared by amyloid diseases at the molecular level., Structures of 13 of these microcrystals all reveal steric zippers, but, with variations that expand the range of atomic architectures for, amyloid-like fibrils and offer an atomic-level hypothesis for the basis of, prion strains.
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<StructureSection load='2ol9' size='340' side='right'caption='[[2ol9]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ol9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OL9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ol9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ol9 OCA], [https://pdbe.org/2ol9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ol9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ol9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ol9 ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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2OL9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OL9 OCA].
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*[[Prion 3D structures|Prion 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
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[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Apostol, M.A.]]
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[[Category: Apostol MA]]
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[[Category: Eisenberg, D.]]
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[[Category: Eisenberg D]]
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[[Category: Sawaya, M.R]]
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[[Category: Sawaya MR]]
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[[Category: beta sheet]]
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[[Category: steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:58:42 2008''
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Current revision

Peptide corresponding to residues 170-175 of human prion

PDB ID 2ol9

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OCA

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