DNase Activity
From Proteopedia
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| - | Many [[Colicin]]s exhibit enzymatic DNase activity as their cytotoxic activity to kill the targeted ''E. coli'' cell. The structure shows the DNase domain of [[Colicin E9]] bound to its [[Colicin Immunity Protein]], [[Im9]]. | + | Many [[Colicin]]s exhibit enzymatic DNase activity as their cytotoxic activity to kill the targeted ''E. coli'' cell. The structure shows the DNase domain of [[Colicin E9]] bound to its [[Colicin Immunity Protein]], [[Im9]]. These kill the cell by selectively cleaving the DNA throughout the genome, which ultimately leads to cell death as the damage is too great for the cell to repair itself. Rather than continue to live with a faulty genome, the cell kills itself. |
This shows just the <scene name='DNase_Activity/Cole9/1'>Colicin E9</scene> DNase domain, as bound to Im9. Here instead shows just the <scene name='DNase_Activity/Im9/1'>Im9</scene> immunity protein. | This shows just the <scene name='DNase_Activity/Cole9/1'>Colicin E9</scene> DNase domain, as bound to Im9. Here instead shows just the <scene name='DNase_Activity/Im9/1'>Im9</scene> immunity protein. | ||
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[[Colicin E8]]<br> | [[Colicin E8]]<br> | ||
[[Colicin E9]]<br> | [[Colicin E9]]<br> | ||
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| + | ==3D structures of colicin== | ||
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| + | [[Colicin]] | ||
Current revision
Many Colicins exhibit enzymatic DNase activity as their cytotoxic activity to kill the targeted E. coli cell. The structure shows the DNase domain of Colicin E9 bound to its Colicin Immunity Protein, Im9. These kill the cell by selectively cleaving the DNA throughout the genome, which ultimately leads to cell death as the damage is too great for the cell to repair itself. Rather than continue to live with a faulty genome, the cell kills itself.
This shows just the DNase domain, as bound to Im9. Here instead shows just the immunity protein.
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| 2k5x, 1 NMR models () | |||||||||
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| Gene: | imm, ceiE9 (Escherichia coli), col, cei (Escherichia coli) | ||||||||
| Related: | 1imq, 1fsj, 1emv | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Colicins with DNase activity
Colicin E2
Colicin E7
Colicin E8
Colicin E9
