3m61

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[[Image:3m61.png|left|200px]]
 
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==Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition==
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The line below this paragraph, containing "STRUCTURE_3m61", creates the "Structure Box" on the page.
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<StructureSection load='3m61' size='340' side='right'caption='[[3m61]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3m61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M61 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m61 OCA], [https://pdbe.org/3m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m61 RCSB], [https://www.ebi.ac.uk/pdbsum/3m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m61 ProSAT]</span></td></tr>
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{{STRUCTURE_3m61| PDB=3m61 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m61_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m61 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition===
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3m61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M61 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: U-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Andreasen, P A.]]
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[[Category: Andreasen PA]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Huang, M.]]
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[[Category: Huang M]]
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[[Category: Jiang, L.]]
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[[Category: Jiang L]]
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[[Category: Meehan, E J.]]
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[[Category: Meehan EJ]]
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[[Category: Wind, T.]]
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[[Category: Wind T]]
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[[Category: Yuan, C.]]
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[[Category: Yuan C]]

Current revision

Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition

PDB ID 3m61

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OCA

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