3r91
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3r91 is ON HOLD Authors: Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Nittoli, T., Otteng, M., Ingalls, C., Golas, J.M., Liu, H., Lucas, J.,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.== | |
| + | <StructureSection load='3r91' size='340' side='right'caption='[[3r91]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3r91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R91 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.579Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06H:(6S)-4,6,15,15,18-PENTAMETHYL-5,17-DIOXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-12,8-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>06H</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r91 OCA], [https://pdbe.org/3r91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r91 RCSB], [https://www.ebi.ac.uk/pdbsum/3r91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r91 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bloom JD]] | ||
| + | [[Category: Boschelli F]] | ||
| + | [[Category: Dushin RG]] | ||
| + | [[Category: Golas JM]] | ||
| + | [[Category: Hu Y]] | ||
| + | [[Category: Ingalls C]] | ||
| + | [[Category: Levin JI]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Lucas J]] | ||
| + | [[Category: McBean JL]] | ||
| + | [[Category: Nittoli T]] | ||
| + | [[Category: Otteng M]] | ||
| + | [[Category: Vogan E]] | ||
| + | [[Category: Zapf CW]] | ||
Current revision
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
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Categories: Homo sapiens | Large Structures | Bloom JD | Boschelli F | Dushin RG | Golas JM | Hu Y | Ingalls C | Levin JI | Liu H | Lucas J | McBean JL | Nittoli T | Otteng M | Vogan E | Zapf CW
