3plz

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[[Image:3plz.jpg|left|200px]]
 
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==Human LRH1 LBD bound to GR470==
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The line below this paragraph, containing "STRUCTURE_3plz", creates the "Structure Box" on the page.
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<StructureSection load='3plz' size='340' side='right'caption='[[3plz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3plz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=470:(3AS,6AR)-5-[(4E)-OCT-4-EN-4-YL]-N,4-DIPHENYL-2,3,6,6A-TETRAHYDROPENTALEN-3A(1H)-AMINE'>470</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_3plz| PDB=3plz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plz OCA], [https://pdbe.org/3plz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3plz RCSB], [https://www.ebi.ac.uk/pdbsum/3plz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3plz ProSAT]</span></td></tr>
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</table>
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===Human LRH1 LBD bound to GR470===
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== Function ==
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[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21391689}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 21391689 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21391689}}
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==About this Structure==
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[[3plz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLZ OCA].
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==Reference==
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<ref group="xtra">PMID:21391689</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Williams, S P.]]
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[[Category: Large Structures]]
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[[Category: Xu, R.]]
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[[Category: Williams SP]]
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[[Category: Zuercher, W J.]]
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[[Category: Xu R]]
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[[Category: Zuercher WJ]]

Current revision

Human LRH1 LBD bound to GR470

PDB ID 3plz

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