2y83

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[[Image:2y83.jpg|left|200px]]
 
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==Actin filament pointed end==
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The line below this paragraph, containing "STRUCTURE_2y83", creates the "Structure Box" on the page.
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<SX load='2y83' size='340' side='right' viewer='molstar' caption='[[2y83]], [[Resolution|resolution]] 22.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2y83]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y83 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 22.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2y83| PDB=2y83 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y83 OCA], [https://pdbe.org/2y83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y83 RCSB], [https://www.ebi.ac.uk/pdbsum/2y83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y83 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The actin filament has clear polarity where one end, the pointed end, has a much slower polymerization and depolymerization rate than the other end, the barbed end. This intrinsic difference of the ends significantly affects all actin dynamics in the cell, which has central roles in a wide spectrum of cellular functions. The detailed mechanism underlying this difference has remained elusive, because high-resolution structures of the filament ends have not been available. Here, we present the structure of the actin filament pointed end obtained using a single particle analysis of cryo-electron micrographs. We determined that the terminal pointed end subunit is tilted towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament. These specific contacts prevent the end subunit from dissociating. For elongation, the loop-to-loop contacts also inhibit the incorporation of another actin monomer at the pointed end. These observations are likely to account for the less dynamic pointed end.
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===ACTIN FILAMENT POINTED END===
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Structural basis for the slow dynamics of the actin filament pointed end.,Narita A, Oda T, Maeda Y EMBO J. 2011 Mar 4. PMID:21378753<ref>PMID:21378753</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2y83" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21378753}}, adds the Publication Abstract to the page
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*[[Actin 3D structures|Actin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21378753 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21378753}}
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__TOC__
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</SX>
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==About this Structure==
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[[Category: Large Structures]]
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[[2y83]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y83 OCA].
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==Reference==
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<ref group="xtra">PMID:21378753</ref><references group="xtra"/>
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Maeda, Y.]]
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[[Category: Maeda Y]]
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[[Category: Narita, A.]]
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[[Category: Narita A]]
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[[Category: Oda, T.]]
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[[Category: Oda T]]

Current revision

Actin filament pointed end

2y83, resolution 22.90Å

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