2kxs

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[[Image:2kxs.jpg|left|200px]]
 
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==ZO1 ZU5 domain in complex with GRINL1A peptide==
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The line below this paragraph, containing "STRUCTURE_2kxs", creates the "Structure Box" on the page.
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<StructureSection load='2kxs' size='340' side='right'caption='[[2kxs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
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{{STRUCTURE_2kxs| PDB=2kxs | SCENE= }}
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</table>
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== Function ==
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===ZO1 ZU5 domain in complex with GRINL1A peptide===
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[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21240187 is the PubMed ID number.
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21240187}}
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[[Category: Synthetic construct]]
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[[Category: Wen W]]
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==About this Structure==
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[[Category: Zhang M]]
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[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_synthetic,_homo_sapiens Homo sapiens, synthetic, homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].
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==Reference==
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<ref group="xtra">PMID:21240187</ref><references group="xtra"/>
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[[Category: Homo sapiens, synthetic, homo sapiens]]
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[[Category: Wen, W.]]
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[[Category: Zhang, M.]]
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Current revision

ZO1 ZU5 domain in complex with GRINL1A peptide

PDB ID 2kxs

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