2l98

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[[Image:2l98.jpg|left|200px]]
 
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==Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C==
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The line below this paragraph, containing "STRUCTURE_2l98", creates the "Structure Box" on the page.
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<StructureSection load='2l98' size='340' side='right'caption='[[2l98]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l98]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L98 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
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{{STRUCTURE_2l98| PDB=2l98 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l98 OCA], [https://pdbe.org/2l98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l98 RCSB], [https://www.ebi.ac.uk/pdbsum/2l98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l98 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN] Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:[https://omim.org/entry/611879 611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15542288</ref> Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:[https://omim.org/entry/613243 613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11385718</ref> <ref>PMID:16302972</ref> <ref>PMID:18572189</ref> <ref>PMID:19439414</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
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===Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C===
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==See Also==
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*[[Troponin 3D structures|Troponin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21226534 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21226534}}
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==About this Structure==
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[[2l98]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L98 OCA].
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==Reference==
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<ref group="xtra">PMID:21226534</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pineda-Sanabria, S E.]]
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[[Category: Large Structures]]
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[[Category: Robertson, I M.]]
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[[Category: Pineda-Sanabria SE]]
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[[Category: Sykes, B D.]]
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[[Category: Robertson IM]]
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[[Category: Sykes BD]]

Current revision

Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C

PDB ID 2l98

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