2hy9

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(New page: 200px<br /><applet load="2hy9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2hy9" /> '''solution structure of the human telomeric qu...)
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[[Image:2hy9.gif|left|200px]]<br /><applet load="2hy9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2hy9" />
 
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'''solution structure of the human telomeric quadruplex'''<br />
 
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==Overview==
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==Human telomere DNA quadruplex structure in K+ solution hybrid-1 form==
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We report the NMR solution structure of the intramolecular G-quadruplex, formed in human telomeric DNA in K(+). The hybrid-type telomeric, G-quadruplex consists of three G-tetrads linked with mixed, parallel-antiparallel G-strands, with the bottom two G-tetrads having the, same G-arrangement (anti:anti:syn:anti) and the top G-tetrad having the, reversed G-arrangement (syn:syn:anti:syn). The three TTA loop segments, adopt different conformations, with the first TTA assuming a, double-chain-reversal loop conformation, and the second and third TTA, assuming lateral loop conformations. The NMR structure is very well, defined, including the three TTA loops and the two flanking sequences at, 5'- and 3'-ends. Our study indicates that the three loop regions interact, with the core G-tetrads in a specific way that defines and stabilizes the, unique human telomeric G-quadruplex structure in K(+). Significantly, a, novel adenine triple platform is formed with three naturally occurring, adenine residues, A21, A3 and A9, capping the top tetrad of the, hybrid-type telomeric G-quadruplex. This adenine triple is likely to play, an important role in the formation of a stable human telomeric, G-quadruplex structure in K(+). The unique human telomeric G-quadruplex, structure formed in K(+) suggests that it can be specifically targeted for, anticancer drug design.
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<StructureSection load='2hy9' size='340' side='right'caption='[[2hy9]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2hy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HY9 FirstGlance]. <br>
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2HY9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy9 OCA], [https://pdbe.org/2hy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy9 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17395643 17395643]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Dai, J.]]
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[[Category: Homo sapiens]]
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[[Category: Hurley, L.]]
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[[Category: Large Structures]]
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[[Category: Jones, R.A.]]
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[[Category: Dai J]]
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[[Category: Punchihewa, C.]]
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[[Category: Hurley L]]
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[[Category: Yang, D.]]
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[[Category: Jones RA]]
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[[Category: g-quadruplex]]
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[[Category: Punchihewa C]]
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[[Category: Yang D]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:09:20 2008''
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Current revision

Human telomere DNA quadruplex structure in K+ solution hybrid-1 form

PDB ID 2hy9

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