Ribosomal protein L19

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[[Image:2xg0.png|left|200px|thumb|Crystal Structure of Ribosomal protein L19 [[2xg0]]]]
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<StructureSection load='' size='350' side='right' scene='Ribosomal_protein_L19/Cv/1' caption='Ribosomal protein L19 (PDB code [[4v5k]])'>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| |right|CAPTION=Ribosomal protein L19 in the 50S subunit [[2xg0]] }}
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== Function ==
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'''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L19/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits<ref>PMID:19799608</ref>.
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'''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits.
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{{TOC limit|limit=2}}
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== Relevance ==
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RPL19 is highly expressed in human breast tumors<ref>PMID:8095182</ref>. RPL19 is a prognostic marker for prostate cancer<ref>PMID:16609016</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein L19 ==
== 3D Structures of Ribosomal protein L19 ==
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===L19 in 50S subunit+RNA===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL19 in 50S subunit+RNA fragments
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47 ]], [[2v49]], [[1vsa]], [[2hgj]], [[ 2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[2xtg]], [[2xux]], [[2xqe]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA]] - Thermus thermophilus
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[[3fin]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
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[[2wwq]] – EcRPL19 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3oas]], [[3oat]], [[3ofd]], [[3og0]], [[3ofq]], [[1vt2]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
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[[3kcr]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
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[[3bbo]] - RPL19 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM<BR /> – spinach
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[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL19 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
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[[1kqs]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA]] - Haloarcula marismortui
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[[1jj2]], [[1ffk]], [[3cc2]], [[3cc4]], [[2otj]], [[2otl]], [[1s72]], [[1qvf]], [[1nji]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA
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[[1qvg]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA (mutant)
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[[3cma]], [[3cme]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-CAP-BIO
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===L19 in 50S subunit + antibiotics===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL19 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+antibiotic
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[[2qam]], [[2qao]], [[2qba]], [[2qbc]], [[2qoz]], [[2qp1]], [[3ofc]], [[3ofz]], [[3ofr]], [[3orb]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+antibiotic
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA+antibiotic
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3cxc]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[3cd6]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+antibiotic
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[[1m90]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
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[[3cpw]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+ linezolid+CCA-Phe-ACA
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===L19 in 50S subunit + ribosome releasing factor (RRF)===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+RRF
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[[2rdo]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<BR />
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===L19 in 50S subunit + various proteins===
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[[2vhm]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
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[[2j28]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<BR />
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[[1w2b]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
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===L19 in the 60S subunit===
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[[3o5h]], [[3o58]] - yRPL19 in 60S subunit+5S RRNA+25S RRNA+5.8S RRNA – yeast
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[[1s1i]] - yRPL19 in 60S subunit+5S RRNA+5.8S RRNA – Cryo EM<BR />
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[[3jyw]] – RPL19 in 60S subunit – Cryo EM<BR /> – Thermomyces lanuginosus
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[[2ftc]] - RPL19 in 60S subunit+16S RRNA – Cryo EM<BR /> – bovine
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[[3izr]] – wRPL19 in the 60S subunit – wheat
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===L19 in large + small ribosomal subunit===
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[[1ml5]] - EcRPL19 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<BR />
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===L19 in the 80S ribosome===
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[[2zkr]] – dRPL19 in 80S ribosome – dog – Cryo EM<BR />
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===L19 in part of 80S ribosome===
===L19 in part of 80S ribosome===
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[[2ww9]], [[2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – Cryo EM<BR />
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[[2ww9]], [[2wwa]] – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<BR />
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[[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – Cryo EM<BR />
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[[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<BR />
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Ribosomal protein L19 (PDB code 4v5k)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L19

Updated on 22-October-2017

L19 in part of 80S ribosome

2ww9, 2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM
2wwb - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM

References

  1. ↑ Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, Yasuda M, Uramoto H, Hanagiri T, Yasumoto K. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. Cancer Sci. 2010 Jan;101(1):46-53. doi: 10.1111/j.1349-7006.2009.01351.x. Epub, 2009 Sep 9. PMID:19799608 doi:http://dx.doi.org/10.1111/j.1349-7006.2009.01351.x
  2. ↑ Henry JL, Coggin DL, King CR. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res. 1993 Mar 15;53(6):1403-8. PMID:8095182
  3. ↑ Bee A, Ke Y, Forootan S, Lin K, Beesley C, Forrest SE, Foster CS. Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2061-5. PMID:16609016 doi:http://dx.doi.org/10.1158/1078-0432.CCR-05-2445

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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