2w6c

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[[Image:2w6c.png|left|200px]]
 
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==ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE==
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The line below this paragraph, containing "STRUCTURE_2w6c", creates the "Structure Box" on the page.
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<StructureSection load='2w6c' size='340' side='right'caption='[[2w6c]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W6C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BM4:3-[(3R)-3-ETHYL-1-{9-[(3S)-3-ETHYL-3-(3-HYDROXYPHENYL)AZEPAN-1-YL]NONYL}AZEPAN-3-YL]PHENOL'>BM4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2w6c| PDB=2w6c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w6c OCA], [https://pdbe.org/2w6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w6c RCSB], [https://www.ebi.ac.uk/pdbsum/2w6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w6c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w6c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A bis-(-)-nor-meptazinol derivative in which the two meptazinol rings are linked by a nonamethylene spacer is a novel acetylcholinesterase inhibitor that inhibits both catalytic activity and Abeta peptide aggregation. The crystal structure of its complex with Torpedo californica acetylcholinesterase was determined to 2.7 A resolution. The ligand spans the active-site gorge, with one nor-meptazinol moiety bound at the "anionic" subsite of the active site, disrupting the catalytic triad by forming a hydrogen bond with His440N(epsilon2), which is hydrogen-bonded to Ser200O(gamma) in the native enzyme. The second nor-meptazinol binds at the peripheral "anionic" site at the gorge entrance. A number of GOLD models of the complex, using both native TcAChE and the protein template from the crystal structure of the bis-(-)-nor-meptazinol/TcAChE complex, bear higher similarity to the X-ray structure than a previous model obtained using the mouse enzyme structure. These findings may facilitate rational design of new meptazinol-based acetylcholinesterase inhibitors.
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===ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE===
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The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(-)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad.,Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL J Med Chem. 2009 Mar 27. PMID:19326912<ref>PMID:19326912</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19326912}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2w6c" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19326912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19326912}}
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==About this Structure==
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[[2w6c]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6C OCA].
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==See Also==
==See Also==
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*[[Acetylcholinesterase]]
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19326912</ref><references group="xtra"/>
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__TOC__
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[[Category: Acetylcholinesterase]]
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</StructureSection>
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[[Category: Torpedo californica]]
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[[Category: Large Structures]]
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[[Category: Fu, W.]]
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[[Category: Tetronarce californica]]
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[[Category: Greenblatt, H M.]]
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[[Category: Fu W]]
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[[Category: Paz, A.]]
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[[Category: Greenblatt HM]]
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[[Category: Qiu, Z.]]
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[[Category: Paz A]]
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[[Category: Silman, I.]]
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[[Category: Qiu Z]]
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[[Category: Sussman, J L.]]
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[[Category: Silman I]]
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[[Category: Tang, Y.]]
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[[Category: Sussman JL]]
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[[Category: Xie, Q.]]
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[[Category: Tang Y]]
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[[Category: Xie Q]]

Current revision

ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE

PDB ID 2w6c

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