3ax1

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'''Unreleased structure'''
 
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The entry 3ax1 is ON HOLD
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==Molecular insights into miRNA processing by Arabidopsis Serrate==
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<StructureSection load='3ax1' size='340' side='right'caption='[[3ax1]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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Authors: Yuan, Y. A., Machida, S., Chen, H.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ax1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX1 FirstGlance]. <br>
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Description: Molecular insights into miRNA processing by Arabidopsis Serrate
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax1 OCA], [https://pdbe.org/3ax1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRRT_ARATH SRRT_ARATH] Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.<ref>PMID:16222298</ref> <ref>PMID:16977334</ref> <ref>PMID:16889646</ref> <ref>PMID:18632569</ref> <ref>PMID:18550839</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Chen HY]]
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[[Category: Machida S]]
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[[Category: Yuan YA]]

Current revision

Molecular insights into miRNA processing by Arabidopsis Serrate

PDB ID 3ax1

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