2orh

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(New page: 200px<br /><applet load="2orh" size="350" color="white" frame="true" align="right" spinBox="true" caption="2orh, resolution 1.90&Aring;" /> '''Directing Macromolec...)
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[[Image:2orh.gif|left|200px]]<br /><applet load="2orh" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2orh, resolution 1.90&Aring;" />
 
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'''Directing Macromolecular Conformation Through Halogen Bonds'''<br />
 
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==Overview==
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==Directing Macromolecular Conformation Through Halogen Bonds==
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The halogen bond, a noncovalent interaction involving polarizable, chlorine, bromine, or iodine molecular substituents, is now being, exploited to control the assembly of small molecules in the design of, supramolecular complexes and new materials. We demonstrate that a halogen, bond formed between a brominated uracil and phosphate oxygen can be, engineered to direct the conformation of a biological molecule, in this, case to define the conformational isomer of a four-stranded DNA junction, when placed in direct competition against a classic hydrogen bond. As a, result, this bromine interaction is estimated to be approximately 2-5, kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to, establish halogen bonding as a potential tool for the rational design and, construction of molecular materials with DNA and other biological, macromolecules.
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<StructureSection load='2orh' size='340' side='right'caption='[[2orh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2orh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orh OCA], [https://pdbe.org/2orh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orh RCSB], [https://www.ebi.ac.uk/pdbsum/2orh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
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==About this Structure==
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Directing macromolecular conformation through halogen bonds.,Voth AR, Hays FA, Ho PS Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665<ref>PMID:17379665</ref>
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2ORH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17379665 17379665]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 2orh" style="background-color:#fffaf0;"></div>
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[[Category: Hays, F.A.]]
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== References ==
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[[Category: Ho, P.S.]]
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<references/>
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[[Category: Voth, A.R.]]
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__TOC__
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[[Category: NA]]
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</StructureSection>
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[[Category: dna holliday junction]]
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[[Category: Large Structures]]
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[[Category: halogen bond]]
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[[Category: Hays FA]]
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[[Category: Ho PS]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:15:18 2008''
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[[Category: Voth AR]]

Current revision

Directing Macromolecular Conformation Through Halogen Bonds

PDB ID 2orh

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