3qo2

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[[Image:3qo2.jpg|left|200px]]
 
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==Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9==
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The line below this paragraph, containing "STRUCTURE_3qo2", creates the "Structure Box" on the page.
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<StructureSection load='3qo2' size='340' side='right'caption='[[3qo2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qo2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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{{STRUCTURE_3qo2| PDB=3qo2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo2 OCA], [https://pdbe.org/3qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo2 ProSAT]</span></td></tr>
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</table>
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===Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9===
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== Function ==
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[https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21419134 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21419134}}
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==About this Structure==
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[[3qo2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO2 OCA].
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==Reference==
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<ref group="xtra">PMID:21419134</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bedford, M T.]]
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[[Category: Large Structures]]
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[[Category: Chang, Y.]]
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[[Category: Synthetic construct]]
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[[Category: Cheng, X.]]
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[[Category: Bedford MT]]
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[[Category: Horton, J R.]]
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[[Category: Chang Y]]
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[[Category: Zhang, X.]]
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[[Category: Cheng X]]
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[[Category: Horton JR]]
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[[Category: Zhang X]]

Current revision

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9

PDB ID 3qo2

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OCA

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