3mnn

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[[Image:3mnn.jpg|left|200px]]
 
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==A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core==
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The line below this paragraph, containing "STRUCTURE_3mnn", creates the "Structure Box" on the page.
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<StructureSection load='3mnn' size='340' side='right'caption='[[3mnn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mnn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MML:1-METHYL-4-(1-METHYLETHYL)BENZENE'>MML</scene>, <scene name='pdbligand=PTW:1,3,5-TRIAZA-7-PHOSPHATRICYCLO[3.3.1.1~3,7~]DECANE'>PTW</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3mnn| PDB=3mnn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnn OCA], [https://pdbe.org/3mnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnn RCSB], [https://www.ebi.ac.uk/pdbsum/3mnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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===A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core===
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3mnn]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNN OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:21344528</ref><references group="xtra"/>
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[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Davey, C A.]]
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[[Category: Davey CA]]
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[[Category: Ong, M S.]]
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[[Category: Ong MS]]

Current revision

A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

PDB ID 3mnn

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