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3m9z

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[[Image:3m9z.jpg|left|200px]]
 
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==Crystal Structure of extracellular domain of mouse NKR-P1A==
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The line below this paragraph, containing "STRUCTURE_3m9z", creates the "Structure Box" on the page.
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<StructureSection load='3m9z' size='340' side='right'caption='[[3m9z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3m9z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M9Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3m9z| PDB=3m9z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m9z OCA], [https://pdbe.org/3m9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m9z RCSB], [https://www.ebi.ac.uk/pdbsum/3m9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m9z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KLRBA_MOUSE KLRBA_MOUSE] Plays a stimulatory role on natural killer (NK) cell cytotoxicity.<ref>PMID:16751398</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Receptors belonging to NKR-P1 family and their specific Clr ligands form an alternative missing self recognition system critical in immunity against tumors and viruses, elimination of tumor cells subjected to genotoxic stress, activation of T cell dependent immune response, and hypertension. The three-dimensional structure of the extracellular domain of the mouse natural killer (NK) cell receptor mNKR-P1Aex has been determined by X-ray diffraction. The core of the C-type lectin domain (CTLD) is homologous to the other CTLD receptors whereas one quarter of the domain forms an extended loop interacting tightly with a neighboring loop in the crystal. This domain swapping mechanism results in a compact interaction interface. A second dimerization interface resembles the known arrangement of other CTLD NK receptors. A functional dimeric form of the receptor is suggested, with the loop, evolutionarily conserved within this family, proposed to participate in interactions with ligands.
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===Crystal Structure of extracellular domain of mouse NKR-P1A===
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Molecular architecture of mouse activating NKR-P1 receptors.,Kolenko P, Rozbesky D, Vanek O, Kopecky V Jr, Hofbauerova K, Novak P, Pompach P, Hasek J, Skalova T, Bezouska K, Dohnalek J J Struct Biol. 2011 Sep;175(3):434-41. doi: 10.1016/j.jsb.2011.05.001. Epub 2011 , May 12. PMID:21600988<ref>PMID:21600988</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3m9z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9Z OCA].
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<div class="pdbe-citations 3m9z" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bezouska, K.]]
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[[Category: Bezouska K]]
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[[Category: Dohnalek, J.]]
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[[Category: Dohnalek J]]
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[[Category: Hasek, J.]]
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[[Category: Hasek J]]
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[[Category: Kolenko, P.]]
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[[Category: Kolenko P]]
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[[Category: Rozbesky, D.]]
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[[Category: Rozbesky D]]

Current revision

Crystal Structure of extracellular domain of mouse NKR-P1A

PDB ID 3m9z

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