2hiv

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[[Image:2hiv.png|left|200px]]
 
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==ATP-dependent DNA ligase from S. solfataricus==
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The line below this paragraph, containing "STRUCTURE_2hiv", creates the "Structure Box" on the page.
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<StructureSection load='2hiv' size='340' side='right'caption='[[2hiv]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HIV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hiv OCA], [https://pdbe.org/2hiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hiv RCSB], [https://www.ebi.ac.uk/pdbsum/2hiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hiv ProSAT]</span></td></tr>
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{{STRUCTURE_2hiv| PDB=2hiv | SCENE= }}
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</table>
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== Function ==
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===ATP-dependent DNA ligase from S. solfataricus===
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[https://www.uniprot.org/uniprot/DNLI_SACS2 DNLI_SACS2] DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.<ref>PMID:12535540</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17052461 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hiv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17052461}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hiv ConSurf].
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[[2hiv]] is a 1 chain structure of [[DNA ligase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIV OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA ligase]]
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17052461</ref><references group="xtra"/>
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__TOC__
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[[Category: Sulfolobus solfataricus]]
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</StructureSection>
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[[Category: Ellenberger, T.]]
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[[Category: Large Structures]]
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[[Category: Pascal, J M.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Atp-dependent]]
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[[Category: Ellenberger T]]
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[[Category: Dna ligase]]
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[[Category: Pascal JM]]
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[[Category: Open conformation]]
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Current revision

ATP-dependent DNA ligase from S. solfataricus

PDB ID 2hiv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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