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Dynactin
From Proteopedia
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| - | [[Image:2hkq.png|left|200px|thumb|Crystal Structure of Dynactin, [[2hkq]]]]
| + | <StructureSection load='2hl5' size='350' side='right' scene='44/444636/Cv/1' caption='Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion [[2hl5]]'> |
| - | {{STRUCTURE_2hkq| PDB=2hkq | SIZE=300| |right|CAPTION=Dynactin subunit 1 CAP-Gly domain complex with protein linker, [[2hkq]] }}
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| - | '''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.
| + | __TOC__ |
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| - | {{TOC limit|limit=2}}
| + | == Function == |
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| | + | '''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> See also [[CAP-Gly domain]]. |
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| | + | == Disease == |
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| | + | Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref> |
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| | + | == Structural highlights == |
| | + | <scene name='44/444636/Cv/3'>Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1</scene> ([[2hl5]]).<ref>PMID:16949363</ref> |
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| | + | == 3D Structures of Dynactin == |
| | + | [[Dynactin 3D structures]] |
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| | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
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| - | | + | == References == |
| - | | + | <references/> |
| - | | + | </StructureSection> |
| - | | + | [[Category:Topic Page]] |
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| - | == 3D Structures of Dynactin == | + | |
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| - | [[2coy]] - hDCTN subunit 1 CAP-Gly domain – human – NMR<br />
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| - | [[3e2u]] – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1<br />
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| - | [[2hkq]], [[2hl3]], [[1txq]] - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal<br />
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| - | [[2hl5]] - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal | + | |
Current revision
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Function
Dynactin (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.[1] See also CAP-Gly domain.
Disease
Mutant dynactin was found in motor neuron disease.[2]
Structural highlights
(2hl5).[3]
3D Structures of Dynactin
Dynactin 3D structures
Updated on 04-May-2025
References
- ↑ Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec;115(6):1639-50. PMID:1836789
- ↑ Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M, Mann E, Floeter MK, Bidus K, Drayna D, Oh SJ, Brown RH Jr, Ludlow CL, Fischbeck KH. Mutant dynactin in motor neuron disease. Nat Genet. 2003 Apr;33(4):455-6. Epub 2003 Mar 10. PMID:12627231 doi:10.1038/ng1123
- ↑ Honnappa S, Okhrimenko O, Jaussi R, Jawhari H, Jelesarov I, Winkler FK, Steinmetz MO. Key interaction modes of dynamic +TIP networks. Mol Cell. 2006 Sep 1;23(5):663-71. PMID:16949363 doi:10.1016/j.molcel.2006.07.013
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