3ode

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[[Image:3ode.png|left|200px]]
 
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==Human PARP-1 zinc finger 2 (Zn2) bound to DNA==
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The line below this paragraph, containing "STRUCTURE_3ode", creates the "Structure Box" on the page.
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<StructureSection load='3ode' size='340' side='right'caption='[[3ode]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ode]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ode| PDB=3ode | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ode FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ode OCA], [https://pdbe.org/3ode PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ode RCSB], [https://www.ebi.ac.uk/pdbsum/3ode PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ode ProSAT]</span></td></tr>
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</table>
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===Human PARP-1 zinc finger 2 (Zn2) bound to DNA===
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 21233213 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21233213}}
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==About this Structure==
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[[3ode]] is a 6 chain structure of [[Poly (ADP-ribose) polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODE OCA].
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==See Also==
==See Also==
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*[[Poly (ADP-ribose) polymerase]]
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:21233213</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Langelier, M F.]]
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[[Category: Large Structures]]
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[[Category: Pascal, J M.]]
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[[Category: Langelier M-F]]
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[[Category: Pascal JM]]

Current revision

Human PARP-1 zinc finger 2 (Zn2) bound to DNA

PDB ID 3ode

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