3nvh

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[[Image:3nvh.png|left|200px]]
 
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==MIHFGND segment 137-143 from mouse prion==
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The line below this paragraph, containing "STRUCTURE_3nvh", creates the "Structure Box" on the page.
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<StructureSection load='3nvh' size='340' side='right'caption='[[3nvh]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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{{STRUCTURE_3nvh| PDB=3nvh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvh OCA], [https://pdbe.org/3nvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nvh RCSB], [https://www.ebi.ac.uk/pdbsum/3nvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvh ProSAT]</span></td></tr>
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</table>
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===MIHFGND segment 137-143 from mouse prion===
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== Disease ==
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[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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== Function ==
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[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_21323366}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 21323366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21323366}}
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==About this Structure==
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[[3nvh]] is a 1 chain structure of [[Prion]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVH OCA].
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==See Also==
==See Also==
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*[[Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:21323366</ref><references group="xtra"/>
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__TOC__
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[[Category: Apostol, M I.]]
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</StructureSection>
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[[Category: Eisenberg, D.]]
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[[Category: Large Structures]]
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[[Category: Sawaya, M R.]]
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[[Category: Mus musculus]]
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[[Category: Apostol MI]]
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[[Category: Eisenberg D]]
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[[Category: Sawaya MR]]

Current revision

MIHFGND segment 137-143 from mouse prion

PDB ID 3nvh

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