2ckc

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[[Image:2ckc.jpg|left|200px]]<br /><applet load="2ckc" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ckc" />
 
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'''SOLUTION STRUCTURES OF THE BRK DOMAINS OF THE HUMAN CHROMO HELICASE DOMAIN 7 AND 8, REVEALS STRUCTURAL SIMILARITY WITH GYF DOMAIN SUGGESTING A ROLE IN PROTEIN INTERACTION'''<br />
 
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==About this Structure==
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==Solution structures of the BRK domains of the human Chromo Helicase Domain 7 and 8, reveals structural similarity with GYF domain suggesting a role in protein interaction==
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2CKC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKC OCA].
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<StructureSection load='2ckc' size='340' side='right'caption='[[2ckc]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2ckc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKC FirstGlance]. <br>
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[[Category: Ab, E.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Daniels, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ckc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckc OCA], [https://pdbe.org/2ckc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ckc RCSB], [https://www.ebi.ac.uk/pdbsum/2ckc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckc ProSAT]</span></td></tr>
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[[Category: Diercks, T.]]
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</table>
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[[Category: Folkers, G.E.]]
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== Disease ==
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[[Category: Jong, R.N.De.]]
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[https://www.uniprot.org/uniprot/CHD7_HUMAN CHD7_HUMAN] CHARGE syndrome;Normosmic congenital hypogonadotropic hypogonadism;Omenn syndrome;Kallmann syndrome. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Kaptein, R.]]
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== Function ==
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[[Category: Xiaoyun, J.]]
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[https://www.uniprot.org/uniprot/CHD7_HUMAN CHD7_HUMAN] Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.<ref>PMID:22646239</ref>
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[[Category: atp-binding]]
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== Evolutionary Conservation ==
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[[Category: brk domain]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: chromatin regulator]]
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Check<jmol>
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[[Category: chromatin remodeling]]
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<jmolCheckbox>
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[[Category: disease mutation]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ckc_consurf.spt"</scriptWhenChecked>
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[[Category: dna-binding]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: helicase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: hydrolase]]
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</jmolCheckbox>
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[[Category: nuclear protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ckc ConSurf].
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[[Category: nucleotide-binding]]
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<div style="clear:both"></div>
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[[Category: phosphorylation]]
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[[Category: protein-protein interaction]]
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[[Category: transcription]]
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[[Category: transcription elongation]]
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[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:20:05 2008''
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==See Also==
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*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ab E]]
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[[Category: Daniels M]]
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[[Category: Diercks T]]
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[[Category: Folkers GE]]
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[[Category: Kaptein R]]
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[[Category: Xiaoyun J]]
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[[Category: De Jong RN]]

Current revision

Solution structures of the BRK domains of the human Chromo Helicase Domain 7 and 8, reveals structural similarity with GYF domain suggesting a role in protein interaction

PDB ID 2ckc

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