2y37

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[[Image:2y37.jpg|left|200px]]
 
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==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==
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The line below this paragraph, containing "STRUCTURE_2y37", creates the "Structure Box" on the page.
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<StructureSection load='2y37' size='340' side='right'caption='[[2y37]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2y37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y37 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A54:2-[(1R)-3-AMINO-1-PHENYL-PROPOXY]-4-CHLORO-BENZONITRILE'>A54</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2y37| PDB=2y37 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y37 OCA], [https://pdbe.org/2y37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y37 RCSB], [https://www.ebi.ac.uk/pdbsum/2y37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y37 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
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===THE DISCOVERY OF NOVEL, POTENT AND HIGHLY SELECTIVE INHIBITORS OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS)===
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).,Cheshire DR, Berg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Kack H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. Epub 2011 Feb 18. PMID:21398123<ref>PMID:21398123</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2y37" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21398123 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21398123}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2y37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y37 OCA].
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==Reference==
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<ref group="xtra">PMID:21398123</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Andrews G]]
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[[Category: Andrews, G.]]
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[[Category: Beaton HG]]
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[[Category: Beaton, H G.]]
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[[Category: Birkinshaw TN]]
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[[Category: Birkinshaw, T N.]]
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[[Category: Boughton-Smith N]]
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[[Category: Boughton-Smith, N.]]
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[[Category: Cheshire DR]]
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[[Category: Cheshire, D R.]]
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[[Category: Connolly S]]
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[[Category: Connolly, S.]]
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[[Category: Cook TR]]
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[[Category: Cook, T R.]]
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[[Category: Cooper A]]
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[[Category: Cooper, A.]]
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[[Category: Cooper SL]]
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[[Category: Cooper, S L.]]
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[[Category: Cox D]]
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[[Category: Cox, D.]]
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[[Category: Dixon J]]
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[[Category: Dixon, J.]]
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[[Category: Gensmantel N]]
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[[Category: Gensmantel, N.]]
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[[Category: Hamley PJ]]
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[[Category: Hamley, P J.]]
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[[Category: Harrison R]]
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[[Category: Harrison, R.]]
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[[Category: Hartopp P]]
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[[Category: Hartopp, P.]]
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[[Category: Kack H]]
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[[Category: Kack, H.]]
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[[Category: Luker T]]
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[[Category: Luker, T.]]
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[[Category: Mete A]]
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[[Category: Mete, A.]]
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[[Category: Millichip I]]
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[[Category: Millichip, I.]]
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[[Category: Nicholls DJ]]
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[[Category: Nicholls, D J.]]
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[[Category: Pimm AD]]
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[[Category: Pimm, A D.]]
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[[Category: St-Gallay SA]]
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[[Category: St-Gallay, S A.]]
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[[Category: Wallace AV]]
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[[Category: Wallace, A V.]]
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Current revision

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

PDB ID 2y37

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