2pd6

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[[Image:2pd6.jpg|left|200px]]<br /><applet load="2pd6" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2pd6, resolution 2.00&Aring;" />
 
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'''Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8'''<br />
 
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==About this Structure==
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==Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8==
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2PD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PD6 OCA].
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<StructureSection load='2pd6' size='340' side='right'caption='[[2pd6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Estradiol 17-beta-dehydrogenase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2pd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PD6 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Arrowsmith, C.H.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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[[Category: Bunkoczi, G.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pd6 OCA], [https://pdbe.org/2pd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2pd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pd6 ProSAT]</span></td></tr>
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[[Category: Delft, F.von.]]
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</table>
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[[Category: Edwards, A.]]
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== Function ==
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[[Category: Gileadi, O.]]
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[https://www.uniprot.org/uniprot/DHB8_HUMAN DHB8_HUMAN] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.<ref>PMID:17978863</ref> <ref>PMID:19571038</ref>
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[[Category: Guo, K.]]
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== Evolutionary Conservation ==
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[[Category: Oppermann, U.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Pike, A.C.W.]]
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Check<jmol>
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[[Category: SGC, Structural.Genomics.Consortium.]]
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<jmolCheckbox>
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[[Category: Salah, E.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/2pd6_consurf.spt"</scriptWhenChecked>
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[[Category: Savitsky, P.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Sundstrom, M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Turnbull, A.P.]]
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</jmolCheckbox>
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[[Category: Ugochukwu, E.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pd6 ConSurf].
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[[Category: Umeano, C.]]
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<div style="clear:both"></div>
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[[Category: Weigelt, J.]]
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[[Category: NAD]]
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[[Category: lipid metabolism]]
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[[Category: sgc]]
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[[Category: short-chain dehydrogenase/reductase]]
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[[Category: steroid metabolism]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:21:51 2008''
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi G]]
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[[Category: Edwards A]]
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[[Category: Gileadi O]]
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[[Category: Guo K]]
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[[Category: Oppermann U]]
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[[Category: Pike ACW]]
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[[Category: Salah E]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull AP]]
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[[Category: Ugochukwu E]]
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[[Category: Umeano C]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8

PDB ID 2pd6

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