2lb7

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[[Image:2lb7.jpg|left|200px]]
 
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==Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif==
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The line below this paragraph, containing "STRUCTURE_2lb7", creates the "Structure Box" on the page.
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<StructureSection load='2lb7' size='340' side='right'caption='[[2lb7]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_kiharae Triticum kiharae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LB7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lb7 OCA], [https://pdbe.org/2lb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2lb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lb7 ProSAT]</span></td></tr>
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{{STRUCTURE_2lb7| PDB=2lb7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMP_TRIKH AMP_TRIKH] Binds chitin. WAMP-1a has antifungal activity against the fungi F.solani (IC(50)=5 ug/ml), F.verticillioides (IC(50)=30 ug/ml), F.oxysporum (IC(50)=5 ug/ml), B.sorokiniana (IC(50)=5 ug/ml), B.cinerea (IC(50)=20 ug/ml) and N.crassa (IC(50)=10 ug/ml). Inhibits hyphal elongation and causes browning of hyphae in F.oxysporum. Causes destruction and discoloration of spores in B.sorokiniana. Inhibits the development of disease caused by the fungus P.infestans on potato tubers. Has antibacterial activity against the Gram-negative bacteria P.syringae and E.carotovora, and the Gram-positive bacterium C.michiganensis.<ref>PMID:19583772</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hevein, a well-studied lectin from the rubber tree Hevea brasiliensis, is the title representative of a broad family of chitin-binding polypeptides. WAMP-1a, a peptide isolated from the wheat Triticum kiharae, shares considerable similarity with hevein. The peptide possesses antifungal, antibacterial activity and is thought to play an important role in the defense system of wheat. Importantly, it features a substitution of the conserved serine residue to glycine reducing its carbohydrate-binding capacity. We used NMR spectroscopy to derive the spatial structure of WAMP-1a in aqueous solution. Notably, the mutation was found to strengthen amphiphilicity of the molecule, associated with its mode of action, an indication of the hevein domain multi-functionality. Both primary and tertiary structure of WAMP-1a suggest its evolutionary origin from the hevein domain of plant chitinases.
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===Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif===
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Solution structure of a defense peptide from wheat with a 10-cysteine motif.,Dubovskii PV, Vassilevski AA, Slavokhotova AA, Odintsova TI, Grishin EV, Egorov TA, Arseniev AS Biochem Biophys Res Commun. 2011 Jul 22;411(1):14-8. Epub 2011 Jun 14. PMID:21704019<ref>PMID:21704019</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lb7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19583772 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19583772}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triticum_kiharae Triticum kiharae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LB7 OCA].
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==Reference==
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<ref group="xtra">PMID:19583772</ref><references group="xtra"/>
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[[Category: Triticum kiharae]]
[[Category: Triticum kiharae]]
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[[Category: Arseniev, A S.]]
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[[Category: Arseniev AS]]
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[[Category: Balashova, T A.]]
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[[Category: Balashova TA]]
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[[Category: Egorov, T A.]]
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[[Category: Egorov TA]]
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[[Category: Grishin, E V.]]
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[[Category: Grishin EV]]
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[[Category: Odintsova, T I.]]
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[[Category: Odintsova TI]]
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[[Category: Vassilevski, A A.]]
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[[Category: Vassilevski AA]]

Current revision

Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif

PDB ID 2lb7

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