3ltl

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[[Image:3ltl.jpg|left|200px]]
 
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==Crystal structure of human BIG1 Sec7 domain==
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The line below this paragraph, containing "STRUCTURE_3ltl", creates the "Structure Box" on the page.
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<StructureSection load='3ltl' size='340' side='right'caption='[[3ltl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ltl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LTL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3ltl| PDB=3ltl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltl OCA], [https://pdbe.org/3ltl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ltl RCSB], [https://www.ebi.ac.uk/pdbsum/3ltl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltl ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human BIG1 Sec7 domain===
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== Function ==
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[https://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3ltl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTL OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Biou, V.]]
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[[Category: Large Structures]]
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[[Category: Cherfils, J.]]
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[[Category: Biou V]]
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[[Category: Joubert, A.]]
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[[Category: Cherfils J]]
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[[Category: Simister, P C.]]
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[[Category: Joubert A]]
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[[Category: Simister PC]]

Current revision

Crystal structure of human BIG1 Sec7 domain

PDB ID 3ltl

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