3n3z

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[[Image:3n3z.jpg|left|200px]]
 
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==Crystal structure of PDE9A (E406A) mutant in complex with IBMX==
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The line below this paragraph, containing "STRUCTURE_3n3z", creates the "Structure Box" on the page.
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<StructureSection load='3n3z' size='340' side='right'caption='[[3n3z]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3n3z| PDB=3n3z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3z OCA], [https://pdbe.org/3n3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3z RCSB], [https://www.ebi.ac.uk/pdbsum/3n3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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===Crystal structure of PDE9A (E406A) mutant in complex with IBMX===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3n3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3Z OCA].
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__TOC__
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y.]]
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[[Category: Large Structures]]
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[[Category: Hou, J.]]
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[[Category: Chen Y]]
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[[Category: Luo, H B.]]
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[[Category: Hou J]]
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[[Category: Xu, J.]]
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[[Category: Luo H-B]]
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[[Category: Zhao, R.]]
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[[Category: Xu J]]
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[[Category: Zou, L.]]
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[[Category: Zhao R]]
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[[Category: Zou L]]

Current revision

Crystal structure of PDE9A (E406A) mutant in complex with IBMX

PDB ID 3n3z

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