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3r1x

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[[Image:3r1x.jpg|left|200px]]
 
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==Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae==
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The line below this paragraph, containing "STRUCTURE_3r1x", creates the "Structure Box" on the page.
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<StructureSection load='3r1x' size='340' side='right'caption='[[3r1x]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r1x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klep7 Klep7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nuw 3nuw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R1X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3r1x| PDB=3r1x | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dgoK, KPN78578_40560, KPN_04097 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272620 KLEP7])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-dehydro-3-deoxygalactonokinase 2-dehydro-3-deoxygalactonokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.58 2.7.1.58] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1x OCA], [https://pdbe.org/3r1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r1x RCSB], [https://www.ebi.ac.uk/pdbsum/3r1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1x ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In most organisms, efficient D-galactose utilization requires the highly conserved Leloir pathway that converts D-galactose to D-glucose 1-phosphate. However, in some bacterial and fungal species alternative routes of D-galactose assimilation have been identified. In the so-called De Ley-Doudoroff pathway, D-galactose is metabolized into pyruvate and D-glyceraldehyde 3-phosphate in five consecutive reactions carried out by specific enzymes. The penultimate step in this pathway involves the phosphorylation of 2-oxo-3-deoxygalactonate to 2-oxo-3-deoxygalactonate 6-phosphate catalyzed by 2-oxo-3-deoxygalactonate kinase, with ATP serving as a phosphoryl-group donor. Here, a crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae determined at 2.1 A resolution is reported, the first structure of an enzyme from the De Ley-Doudoroff pathway. Structural comparison indicates that the enzyme belongs to the ASKHA (acetate and sugar kinases/hsc70/actin) family of phosphotransferases. The protein is composed of two alpha/beta domains, each of which contains a core common to all family members. Additional elements introduced between conserved structural motifs define the unique features of 2-oxo-3-deoxygalactonate kinase and possibly determine the biological function of the protein.
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===Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae===
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Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae.,Michalska K, Cuff ME, Tesar C, Feldmann B, Joachimiak A Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):678-89. Epub 2011, Jul 12. PMID:21795809<ref>PMID:21795809</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3r1x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae Klebsiella pneumoniae subsp. pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1X OCA].
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<div class="pdbe-citations 3r1x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: 2-dehydro-3-deoxygalactonokinase]]
[[Category: 2-dehydro-3-deoxygalactonokinase]]
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[[Category: Klebsiella pneumoniae subsp. pneumoniae]]
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[[Category: Klep7]]
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[[Category: Cuff, M E.]]
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[[Category: Large Structures]]
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[[Category: Feldmann, B.]]
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[[Category: Cuff, M E]]
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[[Category: Joachimiak, A.]]
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[[Category: Feldmann, B]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Joachimiak, A]]
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[[Category: Michalska, K.]]
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[[Category: Structural genomic]]
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[[Category: Tesar, C.]]
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[[Category: Michalska, K]]
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[[Category: Tesar, C]]
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[[Category: 2-keto-3-deoxygalactonate kinase]]
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[[Category: 2-oxo-3-deoxygalactonate kinase]]
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[[Category: Deley-doudoroff pathway]]
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[[Category: Mcsg]]
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[[Category: Psi-biology]]
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[[Category: Transferase]]

Current revision

Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae

PDB ID 3r1x

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