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Crystallin
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| - | + | <StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystallin, [[2g98]]'> | |
| - | + | == Function == | |
| - | ''' | + | '''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystallin are named according to the order they are eluted by gel filtration. δ-crystallin is found in avian and reptilian lenses.<ref>PMID:12729747</ref> |
| - | + | See [[Alpha crystallin]]. | |
| - | == | + | == Disease == |
| - | + | Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>. | |
| - | [[ | + | |
| - | + | == 3D Structures of Crystallin == | |
| - | [[ | + | [[Crystallin 3D structures]] |
| + | |||
| + | </StructureSection> | ||
| + | |||
| + | == References == | ||
| + | <references/> | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747
- ↑ Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:http://dx.doi.org/10.1073/pnas.101124798
