3qeo

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[[Image:3qeo.png|left|200px]]
 
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==S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP==
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The line below this paragraph, containing "STRUCTURE_3qeo", creates the "Structure Box" on the page.
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<StructureSection load='3qeo' size='340' side='right'caption='[[3qeo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.897&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLT:L-DEOXYTHYMIDINE'>LLT</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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{{STRUCTURE_3qeo| PDB=3qeo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qeo OCA], [https://pdbe.org/3qeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qeo RCSB], [https://www.ebi.ac.uk/pdbsum/3qeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qeo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
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===S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP===
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==See Also==
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*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21351740 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21351740}}
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==About this Structure==
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[[3qeo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEO OCA].
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==Reference==
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<ref group="xtra">PMID:21351740</ref><references group="xtra"/>
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[[Category: Deoxycytidine kinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hazra, S.]]
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[[Category: Large Structures]]
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[[Category: Lavie, A.]]
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[[Category: Hazra S]]
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[[Category: Lavie A]]

Current revision

S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP

PDB ID 3qeo

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