3fm0

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[[Image:3fm0.png|left|200px]]
 
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==Crystal structure of WD40 protein Ciao1==
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The line below this paragraph, containing "STRUCTURE_3fm0", creates the "Structure Box" on the page.
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<StructureSection load='3fm0' size='340' side='right'caption='[[3fm0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FM0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3fm0| PDB=3fm0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fm0 OCA], [https://pdbe.org/3fm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fm0 RCSB], [https://www.ebi.ac.uk/pdbsum/3fm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fm0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CIAO1_HUMAN CIAO1_HUMAN] Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.<ref>PMID:17937914</ref> <ref>PMID:20797633</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fm0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fm0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The WD40 domain exhibits a beta-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding modes exhibited by the large versatile family of WD40 domain proteins. In the last part of this review, we will discuss how post-translational modifications are recognized by WD40 domain proteins.
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===Crystal structure of WD40 protein Ciao1===
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Structure and function of WD40 domain proteins.,Xu C, Min J Protein Cell. 2011 Mar;2(3):202-14. Epub 2011 Apr 6. PMID:21468892<ref>PMID:21468892</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21468892}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3fm0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21468892 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21468892}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3fm0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FM0 OCA].
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==Reference==
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<ref group="xtra">PMID:21468892</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Cossar, D.]]
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[[Category: Bountra C]]
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[[Category: Crombet, L.]]
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[[Category: Cossar D]]
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[[Category: Dong, A.]]
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[[Category: Crombet L]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Min, J.]]
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[[Category: Edwards AM]]
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[[Category: Ouyang, H.]]
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[[Category: Min J]]
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[[Category: Ravichandran, M.]]
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[[Category: Ouyang H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Ravichandran M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of WD40 protein Ciao1

PDB ID 3fm0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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