3rc0

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'''Unreleased structure'''
 
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The entry 3rc0 is ON HOLD until Paper Publication
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==Human SETD6 in complex with RelA Lys310 peptide==
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<StructureSection load='3rc0' size='340' side='right'caption='[[3rc0]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rc0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RC0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rc0 OCA], [https://pdbe.org/3rc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rc0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SETD6_HUMAN SETD6_HUMAN] Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity.<ref>PMID:21131967</ref>
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Authors: Chang, Y., Levy, D., Horton, J.R., Peng, J., Zhang, X., Gozani, O., Cheng, X.
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Human SETD6 in complex with RelA Lys310 peptide
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang Y]]
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[[Category: Cheng X]]
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[[Category: Gozani O]]
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[[Category: Horton JR]]
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[[Category: Levy D]]
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[[Category: Peng J]]
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[[Category: Zhang X]]

Current revision

Human SETD6 in complex with RelA Lys310 peptide

PDB ID 3rc0

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