3pkc

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[[Image:3pkc.jpg|left|200px]]
 
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==M. tuberculosis MetAP with bengamide analog Y08, in Mn form==
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The line below this paragraph, containing "STRUCTURE_3pkc", creates the "Structure Box" on the page.
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<StructureSection load='3pkc' size='340' side='right'caption='[[3pkc]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=Y08:(E,2R,3R,4S,5R)-N-[[(3S)-1-CYCLOPROPYLCARBONYLPIPERIDIN-3-YL]METHYL]-2-METHOXY-8,8-DIMETHYL-3,4,5-TRIS(OXIDANYL)NON-6-ENAMIDE'>Y08</scene></td></tr>
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{{STRUCTURE_3pkc| PDB=3pkc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkc OCA], [https://pdbe.org/3pkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkc RCSB], [https://www.ebi.ac.uk/pdbsum/3pkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP12_MYCTU MAP12_MYCTU] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:19688379</ref> <ref>PMID:20038112</ref>
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===M. tuberculosis MetAP with bengamide analog Y08, in Mn form===
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21465667 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21465667}}
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==About this Structure==
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[[3pkc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKC OCA].
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==Reference==
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<ref group="xtra">PMID:21465667</ref><references group="xtra"/>
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[[Category: Methionyl aminopeptidase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Lu, J P.]]
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[[Category: Lu JP]]
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[[Category: Ye, Q Z.]]
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[[Category: Ye QZ]]

Current revision

M. tuberculosis MetAP with bengamide analog Y08, in Mn form

PDB ID 3pkc

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