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(→'''N-methyl-D-aspartate (NMDA) receptor in binding complex with Ketamine''')
Current revision (20:29, 19 February 2012) (edit) (undo)
 
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This sandbox is in use until August 1, 2011 for UMass Chemistry 423. Others please do not edit this page. Thanks!
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<Structure load='2hu4' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!--
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Chem423 Team Projects: Understanding Drug Mechanisms
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Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
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Or use the four-green-boxes-button to insert scrollable text adjacent
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Group Members: Chris Brueckner, Daniel Roy, John Clarkson, Justin Srodulski
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to a Jmol applet. Check out the other buttons as well!
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-->
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{{STRUCTURE_3jpy | PDB=3jpy | SCENE= }}
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== '''N-methyl-D-aspartate (NMDA) receptor in binding complex with Ketamine''' ==
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-Try to included methods of receptor functioning.... Mention AMPA receptors, Kainate receptors, NMDA receptors, with respect to glutamate regulation, also similarities of PCP and Ketamine. Make sure to mention the MG2+ plug in the ionotropic pore of NMDA receptors... how disruption of the ionic flow/balance affects other receptors, and the synapse as a whole.
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(I can help you with this if you need me to)
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Anything that seems too involved, or not closely related enough we can start throwing into the additional information section. I haven't spoken with Justin, so I have no idea how that's going.
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-Chris
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== '''Overall Structure''' ==
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-I think we need at least 3 green scenes... I'll try to have one for PCP and ketamine binding sites, I'm not sure what you need for overall structure. It might be more coherent if we reference specific topics from the introduction.
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-Chris (I'll be back to re-editing this afternoon around 4:30)
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== '''Drug Binding Site''' ==
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[[Image:(S)Ketamine.png|thumb|S-Ketamine Structure]]
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[[Image:PCPMetabolism.png|thumb|PCP in reaction with heat.]]
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== '''Additional Features''' ==
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== '''Credits''' ==
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'''John Clarkson:''' ''Introduction''
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'''Daniel Roy:''' ''Overall Structure''
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'''Chris Brueckner:''' ''Drug Binding Site''
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'''Justin Srodulksi:''' ''Additional Features''
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== '''References''' ==
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# test (PCP Metablite image)
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# (Jerrold Meyer, Psychopharmacology textbook)
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# (Biochem text book)
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# (Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis)
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# (The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia)
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